New Crystalline Betulin-based Materials: Improving Betulin Solubility via Cocrystal Formation
URI (для ссылок/цитирований):
https://www.journals.elsevier.com/materials-today-proceedings/recent-articleshttps://elib.sfu-kras.ru/handle/2311/129723
Дата:
2019-06Журнал:
Materials today: Proceedings.Квартиль журнала в Scopus:
без квартиляКвартиль журнала в Web of Science:
без квартиляБиблиографическое описание:
Myz, S. A. New Crystalline Betulin-based Materials: Improving Betulin Solubility via Cocrystal Formation [Текст] / S. A. Myz, А. В. Михайловская, М. А. Михайленко, Н. В. Булина, С. А. Кузнецова, Т. П. Шахтшнейдер // Materials today: Proceedings.: V International Conference "Fundamental Bases of Mechanochemical Technologies", FBMT-2018, June 25-28, 2018, Novosibirsk, Russia. — 2019. — № 12. — С. 82-85Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.
Аннотация:
The cocrystal formation potential of betulin with aliphatic dicarboxylic acids was investigated. Carboxylic acids of
varying carbon chain length, namely: adipic, succinic and suberic acids, were selected to explore the effect of the
coformer structure on cocrystal formation when liquid-assisted grinding was used. Cocrystal formation was
characterized by powder XRD and IR studies. Betulin cocrystals with adipic acid were successfully synthesized and
HPLC analysis showed that solubility of the betulin cocrystal was significantly improved compared to the initial
betulin and its mechanocomposite with polymer.