Reads in NGS Are Distributed over a Sequence Very Inhomogeneously
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URI (для ссылок/цитирований):
https://link.springer.com/chapter/10.1007%2F978-3-030-17938-0_25https://elib.sfu-kras.ru/handle/2311/129302
Автор:
Michael, Sadovsky
Victory, Kobets
Georgy, Khodos
Dmitry, Kuzmin
Vadim, Sharov
Коллективный автор:
Институт космических и информационных технологий
Кафедра высокопроизводительных вычислений
Дата:
2019-05Журнал:
Lecture Notes in Computer ScienceКвартиль журнала в Scopus:
Q2Квартиль журнала в Web of Science:
без квартиляБиблиографическое описание:
Michael, Sadovsky. Reads in NGS Are Distributed over a Sequence Very Inhomogeneously [Текст] / Sadovsky Michael, Kobets Victory, Khodos Georgy, Kuzmin Dmitry, Sharov Vadim // Lecture Notes in Computer Science. — 2019. — Т. 11465. — С. 271-282Аннотация:
Distribution of read starts over a sequences genetic entity is studied. Key question was whether the starts are distributed uniformly and homogeneously along a sequence, or there exist some spots of the increased local density of the starts. To answer the question, 15 bacterial genomes have been studied. It was found that some genomes exhibit extremely far distribution pattern, from an homogeneity, while others show lower level of the inhomogeneity. The inhomogeneity level was determined through the Kullback-Leibler distance between the real string distribution, and that one bearing the most probable continuations of the shorter strings. © 2019, Springer Nature Switzerland AG.