Reads in NGS Are Distributed over a Sequence Very Inhomogeneously
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URI (для ссылок/цитирований):
https://link.springer.com/chapter/10.1007/978-3-030-17938-0_25https://elib.sfu-kras.ru/handle/2311/129231
Автор:
Садовский, Михаил Георгиевич
Кобец, Виктория Алексеевна
Ходос, Георгий Александрович
Кузьмин, Дмитрий Александрович
Шаров, Вадим Витальевич
Коллективный автор:
Институт фундаментальной биологии и биотехнологии
Базовая кафедра защиты и современных технологии мониторинга лесов
Дата:
2019-05Журнал:
Lectures Notes in BioinformaticsКвартиль журнала в Scopus:
Q2Библиографическое описание:
Садовский, Михаил Георгиевич. Reads in NGS Are Distributed over a Sequence Very Inhomogeneously [Текст] / Михаил Георгиевич Садовский, Виктория Алексеевна Кобец, Георгий Александрович Ходос, Дмитрий Александрович Кузьмин, Вадим Витальевич Шаров // Lectures Notes in Bioinformatics. — 2019. — Т. 11465. — С. 271-282Аннотация:
Distribution of read starts over a sequences genetic entity is studied. Key question was whether the starts are distributed uniformly and homogeneously along a sequence, or there exist some spots of the increased local density of the starts. To answer the question, 15 bacterial genomes have been studied. It was found that some genomes exhibit extremely far distribution pattern, from an homogeneity, while others show lower level of the inhomogeneity. The inhomogeneity level was determined through the Kullback-Leibler distance between the real string distribution, and that one bearing the most probable continuations of the shorter strings.