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The identifiability of patients with carcinogenic somatic mutation of Junus kinase-2 (V617FJAK2) within the framework of programs of dispensary and preventive examinations
Автор | Olkhovskiy, I. A. | |
Автор | Karapetyan, G. E. | |
Автор | Gorbenko, A. S. | |
Автор | Subbotina, T. N. | |
Автор | Stolyar, M. A. | |
Автор | Dyupina, T. N. | |
Автор | Galko, E. V. | |
Дата внесения | 2016-11-11T08:49:22Z | |
Дата, когда ресурс стал доступен | 2016-11-11T08:49:22Z | |
Дата публикации | 2016 | |
Библиографическое описание | Olkhovskiy, I. A. The identifiability of patients with carcinogenic somatic mutation of Junus kinase-2 (V617FJAK2) within the framework of programs of dispensary and preventive examinations [Текст] / I. A. Olkhovskiy, G. E. Karapetyan, A. S. Gorbenko, T. N. Subbotina, M. A. Stolyar, T. N. Dyupina, E. V. Galko // Klinichescheskaya Laboratornaya Diagnostika. — 2016. — Т. 61 (№ 5). — С. 275-278 | |
ISSN | 08692084 | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/27854 | |
Описание | Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала. | |
Аннотация | The article presents results of identification of somatic mutation in in gene Junus kinase-2 (V617F JAK2) in blood samples of persons included in program of dispensarization of adult population and periodic preventive examinations of workers of railroad transport. The technology of allele-specific polymerase chain reaction in real-time in pooled trials from blood samples received by clinical diagnostic laboratory for hematological analysis was developed with purpose of carrying out study. The results of testing among 986persons aged from 45 to 90 years (median - 69 years) permitted to establish 0.7% of patients (3 females and 4 males) with mutation V617F JAK2. The high thrombogenic potential of mutation V617F JAK2 and its involvement into pathogenesis of chronic myeloid tumors makes appropriate to include test on its detection into menu of laboratory analyses of program of dispensarization of population. | |
Ссылка на другой сайт | http://elibrary.ru/item.asp?id=26134196 | |
Тема | СОМАТИЧЕСКАЯ МУТАЦИЯ V617F JAK2 | |
Тема | АЛЛЕЛЬСПЕЦИФИЧЕСКАЯ ПЦР-РВ В ПУЛАХ | |
Тема | ДИСПАНСЕРИЗАЦИЯ НАСЕЛЕНИЯ | |
Тема | SOMATIC MUTATION V617F JAK2 | |
Тема | ALLELE-SPECIFIC POLYMERASE CHAIN REACTION IN REAL-TIME IN POOLS | |
Тема | DISPENSARIZATION OF POPULATION | |
Название | The identifiability of patients with carcinogenic somatic mutation of Junus kinase-2 (V617FJAK2) within the framework of programs of dispensary and preventive examinations | |
Тип | Journal Article | |
Тип | Published Journal Article | |
Страницы | 275-278 | |
ГРНТИ | 76.29.33 | |
Дата обновления | 2016-11-11T08:49:22Z | |
DOI | 10.18821/0869-2084-2016-61-5-275-278 | |
Институт | Институт фундаментальной биологии и биотехнологии | |
Подразделение | Кафедра медицинской биологии | |
Журнал | Klinichescheskaya Laboratornaya Diagnostika | |
Квартиль журнала в Scopus | Q3 |