Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples
URI (for links/citations):http://elib.sfu-kras.ru/handle/2311/27806
Zamay, G. S.
Zamay, T. N.
Kolovskii, V. A.
Shabanov, A. V.
Glazirin, Yu. E.
Veprintsev, D. V.
Krat, A. V.
Zamay, S. S.
Kolovskaya, O. S.
Gargaun, A. E.
Sokolov, A. A.
Modestov, A. A.
Artyukhov, I. P.
Chesnokov, N. V.
Petrova, M. M.
Berezovski, M. V.
Zamay, A. S.
Институт фундаментальной биологии и биотехнологии
Кафедра медицинской биологии
Journal Name:Scientific Reports
Journal Quartile in Scopus:Q1
Journal Quartile in Web of Science:Q1
Bibliographic Citation:Zamay, G. S. Electrochemical aptasensor for lung cancer-related protein detection in crude blood plasma samples [Текст] / G. S. Zamay, T. N. Zamay, V. A. Kolovskii, A. V. Shabanov, Yu. E. Glazirin, D. V. Veprintsev, A. V. Krat, S. S. Zamay, O. S. Kolovskaya, A. E. Gargaun, A. A. Sokolov, A. A. Modestov, I. P. Artyukhov, N. V. Chesnokov, M. M. Petrova, M. V. Berezovski, A. S. Zamay // Scientific Reports. — 2016. — . — .
The development of an aptamer-based electrochemical sensor for lung cancer detection is presented in the work.A highly specific DNA-aptamer, LC-18, selected to postoperative lung cancer tissues was immobilized onto a gold microelectrode and electrochemical measurements were performed in a solution contaning the redox marker ferrocyanide/ferricyanide. As a result, the electrochemical aptasensor was able to detect cancer-related targets in crude blood plasma of lung cancer patients.
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Kim, P. D.; Zamay, S. S.; Zamay, T. N.; Prokopenko, V. S.; Kolovskaya, O. S.; Zamay, G. S.; Princ, V. Ya.; Seleznev, V. A.; Komonov, A. I.; Spivak, E. A.; Rudenko, R. Yu.; Dubinina, A. V.; Komarov, A. V.; Denisenko, V. V.; Komarova, M. A.; Sokolov, A. E.; Narodov, A. A.; Zjivaev, V. P.; Zamay, A. S. (2016)Here we descrabe a method of forming large arrays of free magnetic Ni-nanodiscs 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold-cjated nanodiscs and DNA aptamer ...
Kim, P. D.; Zamay, S. S.; Zamay, T. N.; Procopenko, V. S.; Kolovskaya, O. S.; Zamay, G. S.; Princ, V. Y.; Seleznev, V. A.; Komorov, A. I.; Spivak, E. A.; Rudenko, R. Y.; Dybinina, A. V.; Komarov, A. V.; Denisenko, V. V.; Komarova, M. A.; Sokolov, A. E.; Narodov, A. A.; Zjivaev, V. P.; Zamay, A. S. (2016)Here we describe a method of forming large arrays (up to 109 pieces) of free magnetic Ni nano disks 50 nm thick coated on both sides with layers of 5 nm thick Au. The antitumor effect of the magnetic nickel gold coated ...
Zamay, G. S.; Belyanina, I. V.; Zamay, A. S.; Komarova, M. A.; Krat, A. V.; Eremina, E. N.; Zukov, R. A.; Sokolov, A. E.; Zamay, T. N. (2016)A method of selection of DNA aptamers to breast tumor tissue based on the use of potoperative material has been developed. Breast cancer tissue were used as the positive target; the negative targets included benign tumor ...
Development of a Biosensor for Electrochemical Detection of Tumor-Associated Proteins in Blood Plasma of Cancer Patients by Aptamers Zamay, G. S.; Zamay, T. N.; Kolovskaya, O. S.; Krat, A. V.; Glazirin, Yu. E.; Dubinina, A. V.; Zamay, A. S. (2016)A molecular biosensor based on DNA aptamers (aptasensors) for the diagnosis of lung cancer in blood plasma samples was designed. To create the aptasensor, aptamer 17_80, obtained in the study of postoperative material, was ...
In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field Irina V. Belyanina; Tatiana N. Zamay; Galina S. Zamay; Sergey S. Zamay; Olga S. Kolovskaya; Tatiana I. Ivanchenko; Valery V. Denisenko; Andrey K. Kirichenko; Yury E. Glazyrin; Irina V. Garanzha; Valentina V. Grigorieva; Alexandr V. Shabanov; Dmitry V. Veprintsev; Alexey E. Sokolov; Vladimir M. Sadovskii; Ana, Gargaun; Maxim V. Berezovski; Anna S. Kichkailo (2017-07)Biomedical applications of magnetic nanoparticles in a magnetic field have exceeded many expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various ...