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Thermodynamic Parameters for the Complexation of Water-soluble Betulin Derivatives With (2-hydroxypropy1)-beta-cyclodextrin Determined by Affinity Capillary Electrophoresis
Автор | Сурсякова, В. В. | |
Автор | Левданский, В. А. | |
Автор | Рубайло, А. И. | |
Дата внесения | 2020-01-20T08:03:15Z | |
Дата, когда ресурс стал доступен | 2020-01-20T08:03:15Z | |
Дата публикации | 2019-06 | |
Библиографическое описание | Сурсякова, В. В. Thermodynamic Parameters for the Complexation of Water-soluble Betulin Derivatives With (2-hydroxypropy1)-beta-cyclodextrin Determined by Affinity Capillary Electrophoresis [Текст] / В. В. Сурсякова, В. А. Левданский, А. И. Рубайло // Journal of Molecular Liquids. — 2019. — Т. 283. — С. 325-331 | |
ISSN | 01677322 | |
URI (для ссылок/цитирований) | https://www.sciencedirect.com/science/article/pii/S0167732218362184?via%3Dihub | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/129727 | |
Аннотация | The interaction between (2-hydroxypropy1)beta-cyclodextrin (HP-beta-CD) and water-soluble betulin derivatives, betulin 3,28-disulfate (DSB) and betulin 3-acetate-28-sulfate (ASB), belonging to the class of pentacyclic lupane triterpenoids, was studied using affinity capillary electrophoresis. It was found that 1:1 and 1:2 complexes were formed. The stability constants of the complexes in the temperature range of 293.15-318.15 K were determined. The values obtained are sufficiently large; log K (1:1) and log K (1:2) are 425-5.02 and 6.08-7.59, respectively. This phenomenon can be explained by the presence of broad hydrophobic regions in the molecules of the compound studied. The stability constants decrease with increasing temperature. The stability constants for ASB complexes are slightly higher as compared to the constants for DSB complexes. The thermodynamic parameters for the complexation were calculated from the van't Hoff plots. The complexation was found to be controlled by the enthalpy change. The obtained values of stability constants at 298 K were compared with values for the beta-CD complexes of the compounds under study and for the HP-beta-CD and beta-CD complexes of water-insoluble betulin derivatives. It was found that water-soluble betulin derivatives form more stable complexes with CDs as compared to water-insoluble derivatives (betulonic and betulinic acids), and the HP-beta-CD complexes are more stable than the beta-CD complexes. (C) 2019 Elsevier B.V. All rights reserved. | |
Тема | Binding constants | |
Тема | Cyclodextrins | |
Тема | Drug delivery | |
Тема | Enthalpy | |
Тема | Gibbs energy | |
Тема | Inclusion complexes | |
Название | Thermodynamic Parameters for the Complexation of Water-soluble Betulin Derivatives With (2-hydroxypropy1)-beta-cyclodextrin Determined by Affinity Capillary Electrophoresis | |
Тип | Journal Article | |
Тип | Journal Article Preprint | |
Страницы | 325-331 | |
ГРНТИ | 31.15 | |
Дата обновления | 2020-01-20T08:03:15Z | |
DOI | 10.1016/j.molliq.2019.03.092 | |
Институт | Институт цветных металлов и материаловедения | |
Подразделение | Кафедра органической и аналитической химии | |
Журнал | Journal of Molecular Liquids | |
Квартиль журнала в Scopus | Q1 | |
Квартиль журнала в Web of Science | Q1 |