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Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB)
Автор | Volova, T. G. | |
Автор | Shumilova, A. A. | |
Автор | Nikolaeva, E. D. | |
Автор | Kirichenko, A. K. | |
Автор | Shishatskaya, E. I. | |
Дата внесения | 2020-01-20T07:53:52Z | |
Дата, когда ресурс стал доступен | 2020-01-20T07:53:52Z | |
Дата публикации | 2019-06 | |
Библиографическое описание | Volova, T. G. Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB) [Текст] / T. G. Volova, A. A. Shumilova, E. D. Nikolaeva, A. K. Kirichenko, E. I. Shishatskaya // International Journal of Biological Macromolecules. — 2019. — Т. 131. — С. 230-240 | |
ISSN | 01418130 | |
URI (для ссылок/цитирований) | https://www.sciencedirect.com/science/article/pii/S014181301836851X | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/129003 | |
Аннотация | Hybrid wound dressings have been constructed using two biomaterials: bacterial cellulose (BC) and copolymer of 3-hydroxybutyric and 4-hydroxybutyric acids [P(3HB/4HB)] – a biodegradable polymer of microbial origin. Some of the experimental membranes were loaded with drugs promoting wound healing and epidermal cells differentiated from multipotent adipose-derived mesenchymal stem cells. A study has been carried out to investigate the structure and physical/mechanical properties of the membranes. The in vitro study showed that the most effective scaffolds for growing fibroblasts were composite BC/P(3HB/4HB) films loaded with actovegin. Two types of the experimental biotechnological wound dressings – BC/P(3HB/4HB)/actovegin and BC/P(3HB/4HB)/fibroblasts – were tested in vivo, on laboratory animals with model third-degree skin burns. Wound planimetry, histological examination, and biochemical and molecular methods of detecting factors of angiogenesis, inflammation, type I collagen, and keratin 10 and 14 were used to monitor wound healing. Experimental wound dressings promoted healing more effectively than VoskoPran – a commercial wound dressing. | |
Тема | bacterial cellulose | |
Тема | bioresorbable polyhydroxyalkanoates | |
Тема | composites | |
Тема | properties | |
Тема | hybrids | |
Тема | wound dressings | |
Название | Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB) | |
Тип | Journal Article | |
Тип | Journal Article Preprint | |
Страницы | 230-240 | |
ГРНТИ | 62.13.99 | |
Дата обновления | 2020-01-20T07:53:52Z | |
DOI | 10.1016/j.ijbiomac.2019.03.068 | |
Институт | Институт фундаментальной биологии и биотехнологии | |
Подразделение | Кафедра медицинской биологии | |
Подразделение | Базовая кафедра биотехнологии | |
Журнал | International Journal of Biological Macromolecules | |
Квартиль журнала в Scopus | Q1 | |
Квартиль журнала в Web of Science | Q1 |