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CagA-mediated pathogenesis of helicobacter pylori
Автор | Tohidpour, A. | |
Дата внесения | 2017-06-16T10:28:20Z | |
Дата, когда ресурс стал доступен | 2017-06-16T10:28:20Z | |
Дата публикации | 2016-01 | |
Библиографическое описание | Tohidpour, A. CagA-mediated pathogenesis of helicobacter pylori [Текст] / A. Tohidpour // Microbial Pathogenesis: Review. — 2016. — № 93. — С. 44-55 | |
ISSN | 08824010 | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/33098 | |
Описание | Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала. | |
Аннотация | Helicobacter pylori has been described as the main etiologic agent of gastric cancer, causing a considerable rate of mortality and morbidity in human population across the world. Although the infection mainly begins asymptomatically, but it simply develops to peptic ulcer, chronic gastritis, lymphoma of the gastric mucosa and eventually adenocarcinoma. The major pathological feature of H. pylori infection is due to the activity of the cytotoxin-associated gene A (CagA), a 125-140 kDa protein encoded by the cag pathogenicity island (cagPAI). CagA is also known as the first bacterial onco-protein, ranking the H. pylori-mediated adenocarcinoma as the second most deadly cancer type worldwide. Upon cytoplasmic translocation CagA undergoes interacting with numerous proteins in phosphorylation dependant and independent manners within the gastric epithelial cells. The profound effect of CagA on multiple intracellular pathways causes major consequences such as perturbation of intracellular actin trafficking, stimulation of inflammatory responses and disruption of tight junctions. Such activities of CagA further participate in development of the hummingbird phenotype and gastric cancer. The review is sought to provide a structural and functional analysis of the CagA protein with a focus on demonstrating the molecular basis of the mechanism of CagA intracellular translocation and its interaction with intracellular targets. | |
Ссылка на другой сайт | http://www.sciencedirect.com/science?_ob=ArticleListURL&_method=list&_ArticleListID=-1056867118&_sort=r&_st=13&view=c&md5=4a14aa | |
Тема | Adenocarcinoma | |
Тема | cagPAI | |
Тема | T4SS | |
Тема | EPIYA | |
Тема | Crystal structure | |
Тема | Integrin α5β1 | |
Тема | phosphatidylserine | |
Название | CagA-mediated pathogenesis of helicobacter pylori | |
Тип | Journal Article | |
Тип | Published Journal Article | |
Страницы | 44-55 | |
ГРНТИ | 34.17.15 | |
Дата обновления | 2017-06-16T10:28:20Z | |
DOI | 10.1016/j.micpath.2016.01.005 | |
Институт | Институт фундаментальной биологии и биотехнологии | |
Подразделение | Кафедра биофизики | |
Журнал | Microbial Pathogenesis | |
Квартиль журнала в Scopus | Q2 | |
Квартиль журнала в Web of Science | Q3 |