Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions
DOI:
10.18699/VJ19.516URI (для ссылок/цитирований):
https://vavilov.elpub.ru/jour/article/view/2142https://elib.sfu-kras.ru/handle/2311/129009
Автор:
Shuvaev, A. N.
Belozor, O. S.
Smolnikova, M. V.
Yakovleva, D. A.
Andr.N. Shuvaev
Kazantseva, O. M.
Pozhilenkova, E. A.
Mozhei, O. I.
Kasparov, S.
Коллективный автор:
Институт фундаментальной биологии и биотехнологии
Базовая кафедра медико-биологических систем и комплексов
Дата:
2019-04Журнал:
Vavilovskii Zhurnal Genetiki i SelektsiiКвартиль журнала в Scopus:
Q4Квартиль журнала в Web of Science:
без квартиляБиблиографическое описание:
Shuvaev, A. N. Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions [Текст] / A. N. Shuvaev, O. S. Belozor, M. V. Smolnikova, D. A. Yakovleva, Andr.N. Shuvaev, O. M. Kazantseva, E. A. Pozhilenkova, O. I. Mozhei, S. Kasparov // Vavilovskii Zhurnal Genetiki i Selektsii. — 2019. — Т. 23 (№ 4). — С. 473-481Аннотация:
Hereditary disorders of the neuronal system are some of the most important problems of medicine in the XXI century.
The most interesting representatives of this group are highly prevalent polyglutamine spinocerebellar ataxias (SCAs).
It has a basement for quick progression of expansion among different groups all over the World. These diseases are
SCA1, 2, 3, 6, 7 and 17, which phenotypically belong to one group due to similarities in clinics and genetics. The
substrate of these genetic conditions is CAG trinucleotide repeat of Ataxin genes which may expand in the course
of reproduction. For this reason a characteristic feature of these diseases is not only an increase in patient numbers,
but also a qualitative change in the progression of their neurological symptoms. All these aspects are reflected in the
structure of the incidence of polyglutamine SCAs, both at the global level and at the level of individual population
groups. However, most scientific reports that describe the population genetics of polyglutamine SCAs are limited to
quantitative indicators of a specific condition in a certain area, while the history of the occurrence and principles of
the distribution of polyglutamine SCAs are poorly understood. This prevents long-term predictions of the dynamics of
the disease and development of strategies for controlling the spread of mutations in the populations. In this paper we
make a detailed analysis of the polyglutamine SCAs population genetics, both in the whole world and specifically in
the Russian Federation. We note that for a better analysis it would be necessary to cover a wider range of populations
in Africa, Asia and South America, which will be possible with the development of new methods for molecular genetics.
Development of new methods of detection of polyglutamine SCAs will allow the scientists to better understand how
they lead to the brain disease, the means of their spread in the population and to develop better methods for therapy
and prevention of these diseases.