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Changes in Biological Pathways During 6,000 Years of Civilization in Europe
Автор | Evgeny, Chekalin | |
Автор | Alexandr, Rubanovich | |
Автор | Tatiana, V Tatarinova | |
Автор | Artem, Kasianov | |
Автор | Nicole, Bender | |
Дата внесения | 2020-01-20T07:16:01Z | |
Дата, когда ресурс стал доступен | 2020-01-20T07:16:01Z | |
Дата публикации | 2019-01 | |
Библиографическое описание | Evgeny, Chekalin. Changes in Biological Pathways During 6,000 Years of Civilization in Europe [Текст] / Chekalin Evgeny, Rubanovich Alexandr, V Tatarinova Tatiana, Kasianov Artem, Bender Nicole // Molecular Biology and Evolution. — 2019. — Т. 36 (№ 1). — С. 127-140 | |
ISSN | 07374038 | |
URI (для ссылок/цитирований) | https://academic.oup.com/mbe/article-abstract/36/1/127/5146762?redirectedFrom=fulltext | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/128823 | |
Аннотация | The beginning of civilization was a turning point in human evolution. With increasing separation from the natural environment, mankind stimulated new adaptive reactions in response to new environmental factors. In this paper, we describe direct signs of these reactions in the European population during the past 6,000 years. By comparing whole-genome data between Late Neolithic/Bronze Age individuals and modern Europeans, we revealed biological pathways that are significantly differently enriched in nonsynonymous single nucleotide polymorphisms in these two groups and which therefore could be shaped by cultural practices during the past six millennia. They include metabolic transformations, immune response, signal transduction, physical activity, sensory perception, reproduction, and cognitive functions. We demonstrated that these processes were influenced by different types of natural selection. We believe that our study opens new perspectives for more detailed investigations about when and how civilization has been modifying human genomes. | |
Тема | microevolution | |
Тема | selection | |
Тема | European civilization | |
Тема | adaptation | |
Тема | ancient DNA | |
Тема | pathway analysis | |
Название | Changes in Biological Pathways During 6,000 Years of Civilization in Europe | |
Тип | Journal Article | |
Тип | Journal Article Preprint | |
Страницы | 127-140 | |
ГРНТИ | 34.03.17 | |
Дата обновления | 2020-01-20T07:16:01Z | |
DOI | 10.1093/molbev/msy201 | |
Институт | Институт фундаментальной биологии и биотехнологии | |
Подразделение | Базовая кафедра защиты и современных технологии мониторинга лесов | |
Журнал | Molecular Biology and Evolution | |
Квартиль журнала в Scopus | Q1 | |
Квартиль журнала в Web of Science | Q1 |