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Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery
Автор | Anastasiya, Murueva | |
Автор | Анна, Шершнева | |
Автор | Kseniya, Abanina | |
Автор | Svetlana, Prudnikova | |
Автор | Ekaterina, Shishatskaya | |
Дата внесения | 2019-07-01T07:29:04Z | |
Дата, когда ресурс стал доступен | 2019-07-01T07:29:04Z | |
Дата публикации | 2018-10 | |
Библиографическое описание | Anastasiya, Murueva. Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery [Текст] / Murueva Anastasiya, Шершнева Анна, Abanina Kseniya, Prudnikova Svetlana, Shishatskaya Ekaterina // Drying Technology. — 2018. | |
ISSN | 07373937 | |
URI (для ссылок/цитирований) | https://doi.org/10.1080/07373937.2018.1487451 | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/111287 | |
Аннотация | In this study polymer-based microparticles are used to improve the therapeutic properties of ceftriaxone (CEF) and render them safer. Poly-3-hydroxybutyrate (P3HB) and poly-3-hydroxybutyrate/polyethylene glycol (P3HB-PEG)-based microparticles were prepared by two methods: a double emulsification technique and spray-drying. The microparticles were characterized in terms of size and zeta potential, morphology, total drug loading and drug release. The microparticles had spherical shapes with diameters of a size range from 0.74 to 1.55 µm (emulsification technique) and from 3.84 to 6.51 µm (spray-drying); the encapsulation efficiency of CEF was around 63 % and 49 % for these methods respectively. The CEF release from microparticles obtained by spray-drying reached 100% after 150 hours, while for microparticles obtained by emulsification technique the total release of CEF did not exceed 34% after 312 hours. Antibacterial activity of the microparticles was evaluated against gram-positive and gram-negative bacterial strains. In general, the encapsulation of ceftriaxone in polymeric microparticles preserves the therapeutic efficacy of the CEF and provides a prolonged effect. | |
Тема | Ceftriaxone | |
Тема | PH3B-microparticles | |
Тема | emulsification technique | |
Тема | spray-drying | |
Тема | drug release | |
Тема | antibacterial activity | |
Название | Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery | |
Тип | Journal Article | |
Тип | Journal Article Preprint | |
ГРНТИ | 34.57.21 | |
Дата обновления | 2019-07-01T07:29:04Z | |
DOI | 10.1080/07373937.2018.1487451 | |
Институт | Институт фундаментальной биологии и биотехнологии | |
Подразделение | Лаборатория Биотехнологии новых биоматериалов | |
Журнал | Drying Technology | |
Квартиль журнала в Scopus | Q1 | |
Квартиль журнала в Web of Science | Q2 |