Показать сокращенную информацию

Irina V. Belyanina
Tatiana N. Zamay
Galina S. Zamay
Sergey S. Zamay
Olga S. Kolovskaya
Tatiana I. Ivanchenko
Valery V. Denisenko
Andrey K. Kirichenko
Yury E. Glazyrin
Irina V. Garanzha
Valentina V. Grigorieva
Alexandr V. Shabanov
Dmitry V. Veprintsev
Alexey E. Sokolov
Vladimir M. Sadovskii
Ana, Gargaun
Maxim V. Berezovski
Anna S. Kichkailo
2018-02-07T07:26:51Z
2018-02-07T07:26:51Z
2017-07
Irina V. Belyanina. In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field [Текст] / Irina V. Belyanina, Tatiana N. Zamay, Galina S. Zamay, Sergey S. Zamay, Olga S. Kolovskaya, Tatiana I. Ivanchenko, Valery V. Denisenko, Andrey K. Kirichenko, Yury E. Glazyrin, Irina V. Garanzha, Valentina V. Grigorieva, Alexandr V. Shabanov, Dmitry V. Veprintsev, Alexey E. Sokolov, Vladimir M. Sadovskii, Gargaun Ana, Maxim V. Berezovski, Anna S. Kichkailo // Theranostics. — 2017. — Т. 7 (№ 13). — С. 3326-3337
18387640
http://www.thno.org/v07p3326.htm
https://elib.sfu-kras.ru/handle/2311/69675
Biomedical applications of magnetic nanoparticles in a magnetic field have exceeded many expectations in cancer therapy. Magnetic nanoparticles are effective heat mediators, drug nanocarriers, and contrast agents; various strategies have been suggested to selectively target tumor cancer cells but not healthy cells. Our study presents magnetodynamic nanotherapy utilizing DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for precise elimination of tumor cells in vivo. The cell specific DNA aptamer AS-14 binds to fibronectin protein in Ehrlich carcinoma and delivers gold-coated magnetic nanoparticles to a mouse tumor. An alternating magnetic field of 50 Hz causesthe nanoparticles to oscillate and pull fibronectin and integrins on the surface of the cell membrane resulting in massive cell apoptosis followed by necrosis without heating the tumor, adjacent healthy cells and tissues. The aptamer-guided nanoparticles and the low frequency alternating magnetic field demonstrates a unique technology of a non-invasive nanoscalpel for precise cancer surgery at a single cell level.
сancer therapy
gold coated magnetic nanoparticles
DNA aptamers
low frequency alternating magnetic field
fibronectin
integrin
apoptosis
necrosis
In Vivo Cancer Cells Elimination Guided by Aptamer-Functionalized Gold-Coated Magnetic Nanoparticles and Controlled with Low Frequency Alternating Magnetic Field
Journal Article
Journal Article Preprint
3326-3337
34.17.23
2018-02-07T07:26:51Z
10.7150/thno.17089
Институт математики и фундаментальной информатики
Институт инженерной физики и радиоэлектроники
Базовая кафедра математического моделирования и процессов управления
Кафедра экспериментальной и инновационных технологий
Базовая кафедра вычислительных и информационных технологий
Theranostics
Q1
Q1


Файлы в этом документе

Thumbnail

Данный элемент включен в следующие коллекции

Показать сокращенную информацию