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Biocompatibility of Polyhydroxybutyrate Microspheres: in vitro and in vivo Evaluation
Автор | Shishatskaya, Ekaterina I. | en |
Автор | Voinova, Olga N. | en |
Автор | Goreva, Anastasya V. | en |
Автор | Mogilnaya, Olga A. | en |
Автор | Volova, Tatiana G. | en |
Дата внесения | 2008-02-04T08:24:35Z | |
Дата, когда ресурс стал доступен | 2008-02-04T08:24:35Z | |
Дата публикации | 2008-01 | |
ISSN | 1997-1389 | |
URI (для ссылок/цитирований) | https://elib.sfu-kras.ru/handle/2311/635 | |
Аннотация | Microspheres have been prepared from the resorbable linear polyester of β-hydroxybutyric acid (polyhydroxybutyrate, PHB) by the solvent evaporation technique and investigated in vitro and in vivo. Biocompatibility of the microspheres has been proved in tests in the culture of mouse fibroblast cell line NIH 3Т3 and in experiments on intramuscular implantation of the microspheres to Wistar rats for 3 months. Tissue response to the implantation of polymeric microspheres has been found to consist in a mild inflammatory reaction, pronounced macrophage infiltration that increases over time, involving mono- and poly-nuclear foreign body giant cells that resorb the polymeric matrix. No fibrous capsules were formed around polymeric microparticles; neither necrosis nor any other adverse morphological changes and tissue transformation in response to the implantation of the PHB microparticles were recorded. The results of the study suggest that polyhydroxybutyrate is a good candidate for fabricating prolonged-action drugs in the form of microparticles intended for intramuscular injection. | en |
Размер | 679365 bytes | |
MIME | application/pdf | |
Язык | en | en |
Издатель | Сибирский федеральный университет. Siberian Federal University | en |
Является частью серии | 2008 (1) | en |
Является частью серии | Журнал Сибирского федерального университета. Биология. Journal of Siberian Federal University. Biology | |
Тема | microencapsulation; resorbable polymers; polyhydroxybutyrate; cytotoxicity; tissue response | en |
Название | Biocompatibility of Polyhydroxybutyrate Microspheres: in vitro and in vivo Evaluation | en |
Тип | Journal Article | |
Тип | Published Journal Article | |
Контакты автора | Shishatskaya, Ekaterina I.: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia;shishatskaya@inbox.ru | en |
Контакты автора | Voinova, Olga N.: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia | en |
Контакты автора | Goreva, Anastasya V.: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia | en |
Контакты автора | Mogilnaya, Olga A.: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia | en |
Контакты автора | Volova, Tatiana G.: Institute of Biophysics of Siberian Branch of Russian Academy of Sciences, Akademgorodok, Krasnoyarsk, 660036, Russia; Siberian Federal University, Svobodny av.79, Krasnoyarsk, 660041, Russia | en |
Страницы | 66-77 | |
sfu.metadata.dc.x-file | https://elib.krasu.ru/bitstream/2311/635/1/6_Shishatskaya.pdf |