Effect of Biomaterials of Medical Purpose on the Structural and Functional Features of Monocytes
URI (for links/citations):http://elib.sfu-kras.ru/handle/2311/32943
Menzyanova, N. G.
Nikolaeva, E. D.
Vinokurova, D. V.
Shabanov, A. V.
Shershneva, A. M.
Shishatskaya, E. I.
Sukhova, K. V.
Институт фундаментальной биологии и биотехнологии
Кафедра медицинской биологии
Journal Name:Journal of Siberian Federal University.
Bibliographic Citation:Menzyanova, N. G. Effect of Biomaterials of Medical Purpose on the Structural and Functional Features of Monocytes [Текст] / N. G. Menzyanova, E. D. Nikolaeva, D. V. Vinokurova, A. V. Shabanov, A. M. Shershneva, E. I. Shishatskaya, K. V. Sukhova // Journal of Siberian Federal University.: Biology. — 2016. — Т. 9 (№ 1). — С. 33-42
Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.
The morphological and functional features of the monocytes in a short-term in vitro cultivation on substrates of biopolymer polyhydroxyalkanoate (PHA) in the presence of nanodiamonds (ND) and fullerene (F) were studied. It has been shown that ND and F in the studied concentrations did not affect the viability of monocytes in the short-term culture. The ratio of morphological classes in the presence of ND and F significantly different from the control group of cultivation. Effects of NA and F were characterized by dose-dependent. The formation of a protein corona on the surface of NA and F led to significant changes in the effects of nanoparticles and the formation of new quantitative relationships between morphological classes of monocytes in culture in vitro. The results allow to consider a short-term culture of monocytes in vitro as a model system for adequate assessment of the impact of new materials on the processes of differentiation of monocyte subpopulations.