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Olga S. Belozor
Dariya A. Yakovleva
Ilya V. Potapenko
Andrey N. Shuvaev
Marina V. Smolnikova
Alex, Vasilev
Elena A. Pozhilenkova
Anton N. Shuvaev
2020-01-20T07:53:57Z
2020-01-20T07:53:57Z
2019-04
Olga S. Belozor. Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells [Текст] / Olga S. Belozor, Dariya A. Yakovleva, Ilya V. Potapenko, Andrey N. Shuvaev, Marina V. Smolnikova, Vasilev Alex, Elena A. Pozhilenkova, Anton N. Shuvaev // Brain Sciences. — 2019. — Т. 9 (№ 4). — С. 80-97
20763425
https://www.mdpi.com/2076-3425/9/4/80/htm
https://elib.sfu-kras.ru/handle/2311/129010
Astrogliosis is a pathological process that affects the density, morphology, and function of astrocytes. It is a common feature of brain trauma, autoimmune diseases, and neurodegeneration including spinocerebellar ataxia type 1 (SCA1), a poorly understood neurodegenerative disease. S100β is a Ca 2+ binding protein. In SCA1, excessive excretion of S100β by reactive astrocytes and its uptake by Purkinje cells has been demonstrated previously. Under pathological conditions, excessive extracellular concentration of S100β stimulates the production of proinflammatory cytokines and induces apoptosis. We modeled astrogliosis by S100β injections into cerebellar cortex in mice. Injections of S100β led to significant changes in Bergmann glia (BG) cortical organization and affected their processes. S100β also changed morphology of the Purkinje cells (PCs), causing a significant reduction in the dendritic length. Moreover, the short-term synaptic plasticity and depolarization-induced suppression of synaptic transmission were disrupted after S100β injections. We speculate that these effects are the result of Ca 2+ -chelating properties of S100β protein. In summary, exogenous S100β induced astrogliosis in cerebellum could lead to neuronal dysfunction, which resembles a natural neurodegenerative process. We suggest that astrocytes play an essential role in SCA1 pathology, and that astrocytic S100β is an important contributor to this process.
astrocytes
S100β
Purkinje cells
short-term plasticity
Ca 2+ signaling
Extracellular S100β Disrupts Bergman Glia Morphology and Synaptic Transmission in Cerebellar Purkinje Cells
Journal Article
Journal Article Preprint
80-97
34.15.43
2020-01-20T07:53:57Z
10.3390/brainsci9040080
Институт фундаментальной биологии и биотехнологии
Базовая кафедра медико-биологических систем и комплексов
Brain Sciences
Q2
Q3


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